POTENTIAL INHIBITORY POWER OF "CURCUMA LONGA LINN." EXTRACT AGAINST CANDIDA ALBICANS FUNGUS
Abstract
Oral candidiasis is a fungal infection that often appears on the oral mucosa. These lesions are caused by the fungus Candida albicans. Candida albicans is the most common pathogenic Candida species causing fungal infections of the oral cavity. The use of antifungal drugs is the most common way of giving, but there are many side effects that can be caused. Herbal ingredients that have antifungal effects can be alternative therapies with fewer side effects, one of which is turmeric (Curcuma longa Linn.). Turmeric has various compounds that have the potential as antifungals including curcumin, flavonoids, and essential oils that work by inhibiting the growth of fungi including Candida albicans. The purpose of this literature study is to provide scientific evidence related to the potential inhibition of turmeric extract (Curcuma longa Linn.) against Candida albicans. This writing is a literature study made based on reference sources or references obtained from journals accessed through the databases of Google Scholar, Hindawi, PubMed, Scopus, DOAJ, Research Gate and textbooks. The results of the study stated that turmeric extract had an inhibitory effect on the growth of Candida albicans, the greater the concentration of turmeric extract used, the greater the inhibition caused. Turmeric also has fewer side effects than antifungal drugs.
References
Alafiatayo, A. A., Lai, K. S., Syahida, A., Mahmood, M., & Shaharuddin, N. A. (2019). Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio). Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2019/3807207
Astutiningsih, C., Octaviani, R., & Suratiningsih, S. (2014). Daya hambat minyak atsiri dan ekstrak limbah sisa desilasi rimpang kunir putih (Kaempferia rotunda L.) terhadap pertumbuhan Candida albicansATCC 10231. Jurnal Farmasi Sains Dan Komunitas, 11(1), 18–22. https://doi.org/10.24071/jpsc.0081
Busia, K. (2016). Fundamentals of Herbal Medicine: History, Phytophamacology, and Phytotherapeutics (Vol. 1). Xlibris UK.
Dewayanti, W. (2022). Efektivitas Kunyit (Curcuma longa Linn) Sebagai Anti Jamur. Jurnal Medika Hutama, 03(02), 2019–2024. http://jurnalmedikahutama.com/index.php/JMH/article/view/404
Garcia-Cuesta, C., Sarrion-Pérez, M. G., & Bagán, J. V. (2014). Current treatment of oral candidiasis: A literature review. Journal of Clinical and Experimental Dentistry, 6(5), 576–582. https://doi.org/10.4317/jced.51798
Glick, M. (2015). Burket’s Oral Medicine (12th ed.). People’s Medical Publishing House.
Gow, N. A. R., & Hube, B. (2012). Importance of the Candida albicans cell wall during commensalism and infection. Current Opinion in Microbiology, 15(4), 406–412. https://doi.org/10.1016/j.mib.2012.04.005
Harit, J., Barapatre, A., Prajapati, M., Aadil, K. R., & Senapati, S. (2013). Antimicrobial Activity of Rhizome of Selected Curcuma Variety. International Journal of Life Sciences Biotechnology and Pharma Research, 2(3), 183–189. http://www.ijlbpr.com/index.php?m=content&c=index&a=show&catid=120&id=131
Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A review of its effects on human health. Foods, 6(10), 1–11. https://doi.org/10.3390/foods6100092
Ismarani. (2012). Potensi Senyawa Tannin Dalam Menunjang Produksi Ramah Lingkungan. CEFARS: Jurnal Agribisnis Dan Pengembangan Wilayah, 3(2), 46–55. https://jurnal.unismabekasi.ac.id/index.php/cefars/article/view/94
Moghadamtousi, S. Z., Kadir, H. A., Hassandarvish, P., Tajik, H., Abubakar, S., & Zandi, K. (2014). A review on antibacterial, antiviral, and antifungal activity of curcumin. BioMed Research International, 1–12. https://doi.org/10.1155/2014/186864
Mubarak, Z., Gani, B. A., & Mutia. (2019). Daya Hambat Kunyit (Curcuma longa Linn) Terhadap Pertumbuhan Candida albicans. Cakradonya Dental Journal, 11(1), 1–7. https://doi.org/10.24815/cdj.v11i1.13621
Murugesh, J., Annigeri, R. G., Mangala, G. K., Mythily, P. H., & Chandrakala, J. (2019). Evaluation of the antifungal efficacy of different concentrations of Curcuma longa on Candida albicans: An in vitro study. J Oral Maxillofac Pathol, 23, 305. https://doi.org/10.4103/jomfp.JOMFP
Nadifah, F., Muhajir, N. F., & Retnoningsih, F. (2018). Daya Hambat Minyak Atsiri Rimpang Kunyit terhadap Pertumbuhan Candida albicans In Vitro. Jurnal Vokasi Kesehatan, 4(1), 1–5. https://doi.org/10.30602/jvk.v4i1.124
Neelofar, K., Shreaz, S., Rimple, B., Muralidhar, S., Nikhat, M., & Khan, L. A. (2011). Curcumin as a promising antiCandidal of clinical interest. Canadian Journal of Microbiology, 57(3), 204–210. https://doi.org/https://doi.org/10.1139/W10-117
Paul, S., Mohanram, K., & Kannan, I. (2018). Antifungal activity of curcumin-silver nanoparticles against fluconazole-resistant clinical isolates of Candida species. AYU (An International Quarterly Journal of Research in Ayurveda), 39(3), 182. https://doi.org/10.4103/ayu.ayu_24_18
Prasad, S., & Aggarwal, B. B. (2011). Turmeric, the Golden Spice: From Traditional Medicine to Modern Medicine. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects (2nd editio). CRC Press/Taylor & Francis. https://www.ncbi.nlm.nih.gov/books/NBK92752/
Pulungan, A. S. S. (2017). Aktivitas Antijamur Ekstrak Etanol Daun Kunyit (Curcuma longa Linn.) terhadap Jamur Candida albicans. BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan), 3(2), 124–128. https://doi.org/10.31289/biolink.v3i2.843
Riset Kesehatan Dasar (Riskesdas). (2018). Badan Penelitian dan Pengembangan Kesehatan Kementrian RI tahun 2018.
Septiana, E., & Simanjuntak, P. (2015). Aktivitas Antimikroba dan Antioksidan Ekstrak Beberapa Bagian Tanaman Kunyit (Curcuma longa). Fitofarmaka, 5(1), 31–40. https://doi.org/10.33751/jf.v5i1.193
Singh, A., Verma, R., Murari, A., & Agrawal, A. (2014). Oral candidiasis: An overview. Journal of Oral and Maxillofacial Pathology, 18(5), 81–85. https://doi.org/10.4103/0973-029X.141325
Suharsanti, R., & Wibowo, F. S. (2016). Uji Aktivitas Antijamur Ekstrak Etanol Daun Som Jawa Terhadap Pertumbuhan Candida albicans Untuk Menjamin Mutu Penggunaan Sebagai Obat Herbal Antikeputihan. Media Farmasi Indonesia, 11(2), 1067–1074. https://mfi.stifar.ac.id/MFI/article/view/67
Suraini, & Putri, N. (2018). Efektivitas Anti Jamur Campuran Rebusan Jahe (Zingiber officinale). Prosiding Seminar Kesehatan Perintis, 1(2), 73–77. https://jurnal.upertis.ac.id/index.php/PSKP/article/view/126
Verma, R. K., Kumari, P., Maurya, R. K., Kumar, V., Verma, R., & Singh, R. K. (2018). Medicinal properties of turmeric (Curcuma longa L.): A review. International Journal of Chemical Studies, 6(4), 1354–1357. https://jurnal.unismabekasi.ac.id/index.php/cefars/article/view/94
Wu, J., Lv, M., & Zhou, Y. (2019). Efficacy and side effect of curcumin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trials. Pak J Pharm Sci, 32(1), 43–51. https://pubmed.ncbi.nlm.nih.gov/30772789/