• Mirza Aryanto Department of Endodontics, Faculty of Dentistry Universitas Prof. Dr. Moestopo (Beragama)
  • Siti Nur Khairunnisa Alala Universitas Prof. Dr. Moestopo (Beragama)
Keywords: Propolis, Materials for pulp, Wound healing for pulp


As one of the natural resin materials produced by bees, propolis has been used as a traditional medicine for various diseases because of its biological and pharmacological activities. The purpose of this study was to analyze the potential of propolis as a healing agent for pulp injuries. A total of 35 journals from PubMed, Ebsco, ResearchGate, Wiley Online Library, and other international journal databases were analyzed. Propolis is very rich in active components such as flavonoids that have biological functions such as anti-inflammatory, antibacterial, antifungal and antioxidant which can act as a potential healing agent


Abbasi AJ, Mohammadi F, Bayat M, Gema SM, Ghadirian H, Seifi H et al. Applications of Propolis in Dentistry: a review. Ethiopian Journal of Health Sciences. 2018;28(4).

Alfahdawi I. Chemical Compotitions in Propolis. Propolis in Medicine & Dentistry. Baghdad: Lambert Academic Publishing. 2017:11-12.

Anonymous. Indonesian Ministry of Health. Indonesian Health Profile 2010. Jakarta: Ministry of Health of the Republic of Indonesia, 2011.

Anonymous. Agency for Health Research and Development. Basic Health Research. Jakarta: Ministry of Health of the Republic of Indonesia. 2018.

Bogdanov S. Propolis : Biological Properties and Medical Applications. The Propolis Book 2nd ed.Muehlethurnen: Bee Product Science, 2016:1

Braakhuis A. Evidence on the Health Benefits of Supplemental Propolis. Nutrients. 2019;11(11):2705.

Duncan H.F, Smith AJ, Cooper PR Maintaining Dental Pulp Vitality. In: BS Chung (Editor). Harty's Endodontics in Clinical Practice. 7th ed. London: Elsevier. 2017:70-71.

Esmeraldo MR, Carvalho MG, Carvalho RA, Lima RD, Costa EM Inflammatory Effect of Green Propolis on Dental Pulp in Rats. Brazilian Oral Research. 2013:27:417-22.

Goldberg M. Pulp Anatomy and Characterization of Pulp Cells. In: Goldberg M(Editor). The Dental Pulp: Biology, Pathology, and Regenerative Therapies. New York: Springer,2014:13.

Hadagali MD, Chua LS The Anti-inflammatory and Wound Healing Properties of Honey. European Food Research and Technology.

Holland R, Gomes JE, Cintra LT, Queiroz IO, Estrela C. Factors Affecting The Periapical Healing Process of Endodontically Treated Teeth. Journal of Applied Oral Science. 2017;25:465-76.. 2014;239(6):1003-14.

Inova Newsroom. Wound Healing Center at Inova Loudoun treats complex wound and ostomy casice. Available in: https://www.inovanewsroom.org/ilh/2017/05/wound-healing-center-at-inova-loudoun-treats-complex-wound-and-ostomy-cases/ [Accessed July 19, 2021].

Jain S, Rai R, Sharma V, Batra M. Propolis In Oral Health: A Natural Remedy. World J Pharm Sci 2014; 2(1): 90-94

Kayaoglu G, mürlü H, Akca G, Gürel M, Gençay , Sorkun K et al. Antibacterial Activity of Propolis versus Conventional Endodontic Disinfectants Against Enterococcus faecalis in Infected Dentinal Tubules. Journal of Endodontics. 2011;37(3):376-81.

Khurshid Z, Naseem M, Zafar MS, Najeeb S, Zohaib S. Propolis: A Natural Biomaterial for Dental and Oral Healthcare. Journal of Dental Research, Dental Clinics, Dental Prospects. 2017;11(4):265.

Likitpongpipat N, Sangmaneedet S, Klanrit P, Noisombut R, Krisanaprakornkit S, Chaireltvanitkul P. Promotion of Dental Pulp Wound Healing in New Zealand White Rabbit's Teeth by Thai Propolis Product. Journal of Veterinary Dentistry. 2019;36(1):17-24.

Munir A, Zehnder M, Rechenberg DK Wound Lavage in Studies on Vital Pulp Therapy of Permanent Teeth with Carious Exposures: A Qualitative Systematic Review. Journal of Clinical Medicine. 2020;9(4):984.

Neiva KG, Catalfamo DL, Holliday S, Wallet SM, Pileggi R. Propolis Decreases Lipopolysacchafide-induced inflammatory mediators in pulp cells and osteoclasts. Dental Traumatology. 2014;30(5):362-7.

Oryan A, Mohammadalipor A, Moshiri A, Tabandeh MR Topical application of Aloe vera accelerated wound healing, modeling, and remodeling: an experimental study. Annals of plastic surgery. 2016;77(1):37-46.

Oryan A, Alemzadeh E, Moshiri A. Potential Role of Propolis in Wound Healing: Biological Properties and Therapeutic Activites. Biomedicine & Pharmacotherapy. 2018;98:469-83.

Pasupuleti VR, Sammugam L, Ramesh N, Gan SH Honey, Propolis and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxidative Medicine and Cellular Longevity. 2017.

Prasetyo DH, Suparyanti EL Ethanol Extract Propolis Isolate Reduces Inflammation and Malondialdehyde Levels in Sepsis Model Rat Serum. Bandung Medical Magazine. 2013;45(3):161-6.

Przybylek I, Karpinski TM Antibacterial Properties of Propolis. Molecules. 2019;24(11);2047.

Rahayu RP, Pribadi N, Widjiastuti I, Nugrahani NA Combinations of Propolis and Ca(OH)2 in Dental Pulp Capping Treatments for the Stimulation of Reparative Dentin Formation in a Rat Model. F1000Research. 2020;9.

Rojczyk E, Klama-Baryła A, abuś W, Wilemska-Kucharzewska K, Kucharzewski M. Historical and Modern Research on Propolis and its Application in Wound Healing and Other fields of Medicine and Contributions by Polish Studies. Journal of Ethnopharmacology. 2020:113-159.

Šabanović M, Saltovi S, Avdić-Mujkić A, Jašić M, Bahić Z. Impact of Propolis on the Oral Health. Balkan Journal of Dental Medicine. 2019;23(1):1-9.

Sabir A, Mooduto, L, Kaelan C, Horax S. Impact of the Use of Ethanolic Extract of Propolis, Flavonoid and Non-Flavonoid Propolis for Direct Pulp Capping in Collagen Type I Density. Brazilian Journal of Oral Sciences. 2016;15(4):264-8.

Sabir A. Prospect Of Using Propolis In Conservative Dentistry And Endodontic Treatment (Basic Research Vs Clinical Application). Dentika Dental Journal, Vol 18, No. 2, 2014: 185-189

Santoso ML, Sudirman A, Setyowati L. Minimum Inhibitory Concentration of Propolis Solution against Enterococcus faecalis Bacteria. PDGI Journal. 2012; 61(3):96-101

Sardana D, Indushekar KR, Manchanda S, Saraf BG, Sheoran N. Role of Propolis in Dentistry: a review of the literature. Focus on Alternative and Complementary Therapies. 2013;18(3):118-25.

Scheid RC, Weiss G. Woelfel's Dental Anatomy, Enhanced 9th ed. Massachusetts: Jones & Bartlett Publishers; 2020:12-13

Shah D, Lynd T, Ho D, Chen J, Vines J, Jung HD et al. Pulp-Dentin Tissue Healing Response: A Discussion of Current Biomedical Approaches. Journal of Clinical Medicine. 2020;9(2):434.

Shehu A, Ismail S, Rohin MA, Harun A, Aziz AA, Haque M. Antifungal Properties of Malaysian Tualang Honey and Stingless Bee Propolis Against Candida albicans and Cryptococcus neoformans. Journal of Applied Pharmaceutical Science. 2016;6(2):44-50.

Simon S, Smith AJ, Lumley PJ, Cooper PR, Berdal A. The Pulp Healing Process: From Generation to Regeneration. Endodontic Topics. 2012;26(1):41-56.

Sugiaman VK The Role of Stem Cells in Regenerating Dental Pulp Tissue. SONDE (Sound of Dentistry). 2019;4(1):43- 51

Widjiastuti I, Subiyanto A, Ningtyas EK, Popyandra R, Kurniawan MG, Retnaningsih FD et al. Propolis Extract as Pulp Capping Material Enhances Odontoblast-like Cell Thickness and Type 1 Collagen Expression (in vivo). Dental Journal (Dentistry Magazine). 2020;53(1):1-5.

How to Cite
Aryanto, M., & Alala, S. N. K. (2021). A PROPOLIS AS A HEALING AGENT FOR PULP INJURIES. Moestopo International Review on Social, Humanities, and Sciences, 1(2), 68-76. https://doi.org/10.32509/mirshus.v1i2.16